Edited by LUC MONTAGNIER Centre National de la Recherche Scientifique Institut
Pasteur Paris, France RENE OLIVIER Institut Pasteur Paris, France CATHERINE
PASQUIER Centre National de la Recherche Scientifique Faculte Xavier-Bichat
INSERM U294 Paris, France
(DR. LUC MONTAGNIER is the co-discoverer of the AIDS VIRUS)
Chapter
42
Nutriceutical
Modulation of Glutathione with a Humanized Native Milk Serum Protein Isolate: Application in AIDS and Cancer
Sylvain
Baruchel and Ginette Viau
McGill University-Montreal Children's Hospital Research Institute, Montreal,
Quebec, Canada.
Rene
Olivier
Pasteur, Institute Paris, France
Gustavo
Bounous
Montreal General Hospital, Montreal, Quebec, Canada
Mark
A. Wainberg
Jewish General Hospital, Lady Davis Institute, Montreal, Quebec, Canada
Abstract:
Nutriceutical Modulation Of Glutathione With A Humanized Native Milk Serum
Protein Isolate: Application In AIDS And Cancer.
S. Baruchel, G. Viau, R. Olivier, G. Bounous, M.A. Wainberg [Oxidative
Stress in Cancer, AIDS, and Neurodegenerative Diseases V Luc Montagnier et
al., (Ed.) Marcel Dekker Inc., New York: 447-461, 1998 . ABSTRACT V] The biological
activity of the proteins isolated from cow's milk depends
on the preservation of those labile proteins which share with the predominant
human milk proteins the same extremely rare glutathione (GSH)-promoting components.
This newly discovered nutriceutical modulation of GSH by the use of humanized
native milk serum protein isolate of bovine origin in AIDS and cancer
may well find other applications in disease where oxidative stress and pathology
of GSH metabolism are largely implicated. In a pilot study, this type of
whey protein concentrate was found to be well tolerated in children with AIDS
and wasting syndrome and was found associated with an improvement of the nutritional
status of the patient. Moreover, the GSH promoting activity on
the peripheral blood lymphocyte of this protein concentrate was validated
in patients with initial low GSH levels.