Selectie uit wetenschappelijke studies gerangschikt naar ziektebeeld.
Immuunsysteem / Griep / CVS-ME / Ontgiften / Kanker / HIV-AIDS / Hepatitis / Diabetes / Longziektes / Hart en vaatziektes / Parkinson / Epilepsie / Darmziektes / Antrax / Voedselintolerantie / Sporten

Biologische werking van wei proteïne

The biological activity of undenatured dietary whey proteins: role of glutathione, Bounous G, Gold P Department of Surgery, Montreal General Hospital Research Institute, Quebec. "The presence in the serum albumin fraction of glutamylcysteine groups (rare in food protein) and the specific intramolecular bond as related to the undenatured conformation of the molecule are considered to be key factors in the glutathione-promoting activity of the protein mixture."

The influence of dietary whey protein on tissue glutathione and the diseases of aging Bounous G, Gervais F, Amer V, Batist G, Gold P Montreal General Hospital Research Institute, Quebec. "Hence a whey protein diet appears to enhance the liver and heart glutathione concentration in aging mice and to increase longevity over a 6.3 month observation period." 


Glutathion, Wei proteïne en Immuunsysteem

The immunoenhancing property of dietary whey protein concentrate, 

Immunoenhancing property of dietary whey protein in mice: role of glutathione,

Influence Of Dietary Lactalbumin Hydrolysate On The Immune System Of Mice And Resistance To Salmonellosis  

Glutathione protects mice from lethal sepsis by limiting inflammation and potentiating host defense.  

Glutathione-induced enhancement of neutrophil locomotion.  

Glutathion en griep

Uit verschillende onderzoeken blijkt dat goede bloedwaarden glutathion zeer belangrijk zijn ter voorkoming van en voor een flinke vermindering van de klachten en de duur van de griep, zeker bij mensen met longproblemen zoals astma en COPD. Goede bloedwaarden glutathion zorgen voor een goed natuurlijk immuunsysteem dat de infectie goed en snel kan bestrijden en wellicht kan voorkomen.

Een greep uit die onderzoeken:

Inhibition of influenza infection by glutathione.

Occurence, structure, biochemical properties and technological characteristics of lactoferrin. Jan M. Steijns* and A. C. M. van Hooijdonk

Effect of dietary whey protein concentrate on primary and secondary antibody responses in immunized BALB/c mice P. P. L. Low1, K. J. Rutherfurd, H. S. Gill and M. L. Cross

Influenza A virus replication is dependent on an antioxidant pathway that involves GSH and Bcl-2.

Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment. (The researchers suggest that glutathione “provides an alternate [to antiviral drugs] strategy to limiting influenza infection.” )

GSH and analogs in antiviral therapy

Decreased Selenoprotein Expression Alters the Immune Response during Influenza Virus Infection

Glutathione Metabolism and Its Implications for Health

Glutathione Is Required for Efficient Production of Infectious Picornaviruses Virions

A nutritional supplement formula for influenza A (H5N1) infection in humans. (Note: the form of cysteine used was not the clinically best formulation available. There are products that are even better at producing glutathione. They even have clinical proof of their effectiveness.)

Anti-influenza activity of glutathione, Handbook of Antioxidants.Enrique Cadenas, Lester Packer

 

Uit dit handboek een schema van de invloed van glutathion op het influenzavirus:


Het oppervlakte-eiwit van griepvirussen, hemagglutinine speelt een sleutelrol in de beginfase van een griepinfectie: het zorgt voor de binding aan de receptor en het samengaan van virus en celmembranen. Glutathion zorgt in deze beginfase ervoor dat de rol van hemagglutinine meer of minder wordt gereduceerd afhankelijk van de hoeveelheid glutathion.
(De antivirale Neuraminidase blokkers zoals Tamiflu proberen daarentegen de verspreiding van virusdeeltjes tegen te gaan)

Glutathion en CVS-ME

The Clinical Management of Chronic Fatigue Syndrome (CFS, CFIDS) - transcript of a workshop by Paul Cheney, M.D., one of the leading authorities on Chronic Fatigue Syndrome and Fibromyalgia in the U.S., and founder/director of the Cheney Clinic, Feb. 1999. This study emphasized the central role of glutathione deficiency in the symptomology of Chronic Fatigue Syndrome.

 


Glutathion en ontgiften

Cysteine metabolism and metal toxicity  

Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity.  

Chronic ethanol and nicotine interaction on rat tissue antioxidant defense system. 


Glutathion, Wei proteïne en Kanker:

( zie ook meer informatie over Glutathion en kanker.)

Glutathion helpt met vis tegen borstkanker.

Dat het eten van vis speciaal vette vis (zoals zalm, makreel,..) gezond is was reeds bekend. De hierin aanwezige omega3 vetzuren worden verantwoordelijk gehouden voor de kanker beschermende eigenschappen. Door veel vis te eten daalt de kans op borstkanker met wel 35%. Uit onderzoek onder 63.000 Chinezen in Signapore is nu gebleken dat vrouwen waarbij bepaalde Glutathiongenen (genen die de aanmaak van Glutathion regelen ) meer actief zijn tot wel 74% minder kans hebben op borstkanker. (sept.2004)

 

De rol van Glutathion en kanker.

In een uitgave van Cell Bochemistry and Function wordt dieper ingegaan op de beschermende rol van Glutathion en kanker. (aug. 2004)

Cysteine-GSH and Prostate Cancer. (Apr. 2004)

GSH depletion enhances adenoviral bax-induced apoptosis in lung cancer cells.

Redox regulation of pancreatic cancer cell growth: role of glutathione peroxidase in the suppression of the malignant phenotype.

AMERICAN ASSOCIATION FOR CANCER RESEARCH : HIGH CYSTEINE LEVELS LINKED TO LOWER RATES OF BREAST CANCER
Dr. Shumin Zhang, m.d., Sc.D., Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (USA), July 2003.
Journalist : Brian Reid from Doctor's Guide
(PDF file of 19 Kb) 

WHEY PROTEIN CONCENTRATE (WPC) AND GLUTATHIONE MODULATION IN CANCER TREATMENT : CASE REPORTS
DR. GUSTAVO BOUNOUS, MD, F.R.C.S. (C)
PUBLISHED IN ANTICANCER RESEARCH, INTERNATIONAL JOURNAL OF CANCER RESEARCH AND TREATMENT
Clinical Studies Section, November/December 2000.
(PDF file of 331 Kb) 

OXIDATIVE STRESS IN CANCER, AIDS AND NEURODEGENERATIVE DISEASES, Chapitre 42, 1998
Authors : Luc Montagnier and Rene Olivier from Pasteur Institute, Paris, France
Catherine Pasquier, National Center of Scientific Research, Paris, France.
(PDF file of 115 Kb) 

Enchancing effect of patented whey protein isolate (Immunocal®) on cytotoxicity of an anticancer drug.  

Whey proteins in cancer prevention.

Effect of adding glutathione (GSH) to cisplatin (CDDP) in the treatment of stage I-IV ovarian cancer  

Whey protein concentrate (WPC) and glutathione modulation in cancer treatment.

In vitro selective modulation of cellular glutathione by a humanized native milk protein isolate in normal cells and rat mammary carcinoma model.

The use of a whey protein concentrate in the treatment of patients with metastatic carcinoma: a phase I-II clinical study.  

Dietary whey protein inhibits the development of dimethylhydrazine induced malignancy.  

Dairy proteins protect against dimethylhydrazine-induced intestinal cancers in rats.

Milk and dairy products in cancer prevention: focus on bovine lactoferrin.  

Prevention of colon carcinogenesis and carcinoma metastasis by orally administered bovine lactoferrin in animals.

Modulation of glutathione by a cysteine pro-drug enhances in vivo tumor response.

Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs.  

Glutathione and glutathione-dependent enzymes in cancer drug resistance.

Colon cancer: dietary modifications required for a balanced protective diet.

Role of GSH/GST-dependent Detoxification System in Chemoprevention
Een slide show over de rol van antioxidanten in de bestrijding van kanker. (PDF version)


Glutathion en HIV-AIDS:

(zie ook meer informatie over HIV-Aids)

Glutathione inhibits HIV replication by acting at late stages of the virus life cycle.

Intracellular glutathione as a possible direct blocker of HIV type 1 reverse transcription.  

Glutathione deficiency is associated with impaired survival in HIV disease.  

Low serum thiol levels predict shorter times-to-death among HIV-infected injecting drug users  

Oral supplementation with whey proteins increases plasma glutathione levels of HIV-infected patients.  

Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients. 

Whey proteins as a food supplement in HIV-seropositive individuals.  

The role of oxidative stress in disease progression in individuals infected by the human immunodeficiency virus.

Effects of whey protein and resistance exercise on body composition and muscle strength in women with HIV infection.  

Glutathione and cysteine in HIV-infected hemophiliacs.

Decreased release of glutathione into the systemic circulation of patients with HIV infection.  

Correction of glutathione deficiency in the lower respiratory tract of HIV seropositive individuals by glutathione aerosol treatment.  

Can HIV infection be treated with antioxidants?  

Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. 

Role of cysteine and glutathione in signal transduction, immunopathology and cachexia.

Massive loss of sulfur in HIV infection.  

Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice.

Glutathione and HIV infection: reduced reduced, or increased oxidized?

Micronutrient status in relationship to mortality in HIV-1 disease.

Antioxidant supplementation in HIV/AIDS.


Glutathion, ImmunoPro en Hepatitis

Nutritional therapy of chronic hepatitis by whey protein (non-heated).

Lactoferrin* inhibits hepatitis C virus viremia in patients with chronic hepatitis C: a pilot study.  

Lactoferrin is one of the thermolabile proteins in ImmunoPro


Glutathion en Diabetes 

Influence of reduced glutathione infusion on glucose metabolism in patients with non-insulin-dependent diabetes mellitus.

Glutathione in human plasma: Decline in association with aging, age- related macular degeneration, and diabetes.  

Intracellular reduced glutathione content in normal and type 2 diabetic erythrocytes: effect of insulin and (-)epicatechin. 


 Glutathione en Longziektes

Glutathione: in defense of the lung.  

Systemic deficiency of glutathione in cystic fibrosis. 

Lymphocyte glutathione levels in children with cystic fibrosis.

Erythrocytic glutathione in cystic fibrosis. A possible marker of pulmonary dysfunction.  

Treatment of obstructive airway disease with a cysteine donor protein supplement: a case report.  

Evidence of a defective thiol status of alveolar macrophages from COPD patients and smokers. Chronic obstructive pulmonary disease.  

Altered glutamate metabolism is associated with reduced muscle glutathione levels in patients with emphysema.  

Evidence for oxidative stress in bronchiolitis obliterans syndrome after lung and heart- lung transplantation.  

The effects of chronic alcohol abuse on pulmonary glutathione homeostatis.  

CFTR, Glutathione and Neutrophil Function
Een slide show van de Stanford University Medical Center over Cystic Fibrosis and Glutathione


Glutathion, Wei proteïne en Hart- en vaatziektes

Glutathion helpt bloeddruk te normaliseren.

Glutathion is de beste anti-oxidant om de bloeddruk te normaliseren volgens een Italiaans onderzoek. (juni 2004)

Glutathion waarden maat voor risico op hart- en vaatziektes

Bioactive Components of Whey and Cardiovascular Health (pdf) 

Oxidant stress in the vasculature.

Erythrocyte susceptibility to lipid peroxidation in patients with coronary atherosclerosis  

L-2-oxothiazolidine-4- carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease.  

Serum glutathione in adolescent males predicts parental coronary heart disease.  

Glutathione reverses endothelial dysfunction and improves nitric oxide bioavailability. 

Macrophage foam cell formation during early atherogenesis is determined by the balance between pro-oxidants and anti-oxidants in arterial cells and blood lipoproteins.  

Hyperglycemia in diabetic rats reduces the glutathione content in the aortic tissue. 

Effect of administration of fermented milk containing whey protein concentrate to rats and healthy men on serum lipids and blood pressure.

Effect of milk protein and fat intake on blood pressure and the incidence of cerebrovascular diseases in stroke-prone spontaneously hypertensive rats (SHRSP)  

Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides

Lactokinins: whey protein-derived ACE inhibitory peptides

Glutathione deficiencies exacerbate response to stroke


 Glutathion en de ziekte van Parkinson

(zie ook meer over de Ziekte van Parkinson)

Glutathione, oxidative stress and neurodegeneration. 

Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients.

Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia  

Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease.  

Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson's disease. 

Does oxidative stress participate in nerve cell death in Parkinson's disease?  

Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease.  

Depletion of brain glutathione potentiates the effect of 6-hydroxydopamine in a rat model of Parkinson's disease.  

Decreased glutathione results in calcium-mediated cell death in PC12.  

Glutathione depletion switches nitric oxide neurotrophic effects to cell death in midbrain cultures: implications for Parkinson's disease. 

Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease.  

[Case-control study of markers of oxidative stress and metabolism of blood iron in Parkinson's disease]


Glutathion en Epilepsie

Glutathione peroxidase deficiency and childhood seizures. 


Glutathion en darmziektes

Glutathione metabolism in Crohn's disease.

Low levels of glutathione in endoscopic biopsies of patients with Crohn's colitis: the role of malnutrition. 

Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease.  

Replenishment of Glutathione Levels Improves Mucosal Function in Experimental Acute Colitis  


 Glutathione and Malnutrition
In vivo rates of erythrocyte glutathione synthesis in children with severe protein-energy malnutrition.  


Glutathion en sporten

EFFECT OF SUPPLEMENTATION WITH A CYSTEINE DONOR ON MUSCULAR PERFORMANCE
L.C. Lands, V.L. Grey and A.A. Smountas
Division of Respiratory Medicine, Department of Pediatrics, and Department of Biochemistry, McGill University Health Centre-Montreal Children's Hospital, Montreal, Quebec, Canada, June 1999 (PDF file of 70 Kb). 

The effect of whey protein supplementation with and without creatine monohydrate combined with resistance training on lean tissue mass and muscle strength.  

Physical exercise intensity can be related to plasma glutathione levels. 

Oxidants, antioxidant nutrients and the athlete.  

Antioxidants and physical performance.  

Mitochondria changes in human muscle after prolonged exercise, endurance training and selenium supplementation. 

Reductions in blood glutamine concentration following intense exercise may contribute to immune suppression in overtrained athletes