Hoge
dosis vitamine C als kankertherapie.*
Terwijl
uit oudere studies uitgevoerd door Linus Pauling afgeleid kon worden dat
vitamine C zowel oraal toegediend als intraveneus goed was bij kanker
toonden studies uitgevoerd aan de Mayo Clinic aan er geen voordelen waren
van oraal toegediende vitamine C. Uit nieuwe studies blijkt dat vitamine C,
intraveneus toegediend, in zeer hoge dosis inderdaad positieve resultaten
geeft bij kankerpatiënten. De hoeveelheden vitamine C varieerde van 2 tot 3
keer per week 15 –30 gram vitamine C, en dat enkele maanden lang.
High-dose
Vitamin C As A Cancer Therapy
Although
early clinical studies conducted by Linus Pauling showed that high-dose
vitamin C, given by intravenous and oral routes, may improve symptoms and
prolong life in patients with terminal cancer, no benefits for cancer
patients were seen when vitamin C therapy was administered orally in
double-blind placebo-controlled studies at the Mayo Clinic. Since then, high
doses of vitamin C have been used only as an "alternative" therapy
to standard cancer treatment. However, recent evidence shows that
intravenous administration of the maximum tolerated dose of vitamin C
produces plasma concentrations about 25 times higher than when the vitamin
is administered orally. At concentrations above 1000 mmol/L -- which can
only be achieved by the intravenous route -- vitamin C is toxic to some
cancer cells but not to normal cells in vitro.
Padayatty and colleagues report on 3 well-documented cases of advanced
cancers, confirmed by histopathologic review, where patients had
unexpectedly long survival times after receiving high-dose intravenous
vitamin C therapy. They assessed the clinical details of each case in
accordance with National Cancer Institute (NCI) Best Case Series guidelines,
and found that the case reports indicate that the role of high-dose
intravenous vitamin C therapy in cancer treatment should be reassessed.
###
p. 937 Intravenously administered vitamin C as cancer therapy: three cases
-- S.J. Padayatty et al
Contact:
Marcia Vital
Canadian
Medical Association Journal
( april 2006)