Vitamine D tegen vallen door ouderen.*
Uit een studie onder ouderen blijkt dat 5 maanden supplementering met 20 mcg vitamine D per dag de kans op een val met een 72% doet verminderen. Lagere dosis vitamine D doen het risico niet verminderen. Normaal valt een oudere (ouder dan 70 jaar) gemiddeld 1 keer per jaar, zij die ziek zijn of al eerder gevallen zijn vallen meestal vaker met alle mogelijke nare gevolgen van dien. 20 mcg vitamine D is toch bijna het dubbele van de geadviseerde dagelijkse hoeveelheid.
BRIEF
REPORTS
A
Higher Dose of Vitamin D Reduces the Risk of Falls in Nursing Home Residents: A
Randomized, Multiple-Dose Study
Kerry E. Broe, MPH Institute
for Aging Research, Hebrew SeniorLife, Boston, Massachusetts; ,
Tai C. Chen, PhD Vitamin
D Laboratory, Department of Medicine, Boston Medical Center, Boston,
Massachusetts; ,
Janice Weinberg, ScD Department
of Biostatistics, Boston University School of Public Health, Boston,
Massachusetts; ,
Heike A. Bischoff-Ferrari, MD, MPH Department
of Rheumatology and Institute of Physical Medicine and Rehabilitation,
University Hospital Zurich, Zurich, Switzerland, Department
of Nutrition, Harvard School of Public Health, Boston, Massachusetts; and ,
Michael F. Holick, MD, PhD Vitamin
D Laboratory, Department of Medicine, Boston Medical Center, Boston,
Massachusetts; , and
Douglas P. Kiel, MD, MPH Institute
for Aging Research, Hebrew SeniorLife, Boston, Massachusetts; Division
on Aging, Harvard Medical School, Boston, Massachusetts.
From the *Institute for Aging
Research, Hebrew SeniorLife, Boston, Massachusetts; Vitamin D Laboratory,
Department of Medicine, Boston Medical Center, Boston, Massachusetts; Department
of Biostatistics, Boston University School of Public Health, Boston,
Massachusetts; Department of Rheumatology and Institute of Physical Medicine and
Rehabilitation, University Hospital Zurich, Zurich, Switzerland, Department of
Nutrition, Harvard School of Public Health, Boston, Massachusetts; and ¶Division
on Aging, Harvard Medical School, Boston, Massachusetts.
Address correspondence to Kerry E.
Broe, Institute for Aging Research, Hebrew SeniorLife, 1200 Center Street,
Roslindale, MA 02131. E-mail: broe@hrca.harvard.edu
Abstract
OBJECTIVES: To
determine the effect of four vitamin D supplement doses on falls risk in elderly
nursing home residents.
DESIGN: Secondary
data analysis of a previously conducted randomized clinical trial.
SETTING: Seven
hundred twenty-five-bed long-term care facility.
PARTICIPANTS: One
hundred twenty-four nursing home residents (average age 89).
INTERVENTION: Participants
were randomly assigned to receive one of four vitamin D supplement doses (200 IU,
400 IU, 600 IU, or 800 IU) or placebo daily for 5 months.
MEASUREMENTS: Number
of fallers and number of falls assessed using facility incident tracking
database.
RESULTS: Over
the 5-month study period, the proportion of participants with falls was 44% in
the placebo group (11/25), 58% (15/26) in the 200 IU group, 60% (15/25) in
the 400 IU group, 60% (15/25) in the 600 IU group, and 20% (5/23) in
the 800 IU group. Participants in the 800 IU group had a 72% lower
adjusted-incidence rate ratio of falls than those taking placebo over the 5
months (rate ratio=0.28; 95% confidence interval=0.11–0.75). No significant
differences were observed for the adjusted fall rates compared to placebo in any
of the other supplement groups.
CONCLUSION: Nursing home residents in the highest vitamin D group (800 IU) had a lower number of fallers and a lower incidence rate of falls over 5 months than those taking lower doses. Adequate vitamin D supplementation in elderly nursing home residents could reduce the number of falls experienced by this high falls risk group. (Maart 2007) (Opm. Meer over voeding en vitamine D)