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Kurkuma tegen ontstekingen en goed bij retinopathie.*

Uit een dierenstudie met ratten blijkt dat kurkuma goed werk doet tegen ontstekingen en tegen oxidatieschade. Oxidatieschade en ontstekingen liggen mede ten grondslag aan retinopathie (aantastingen van het netvlies) bij mensen met diabetes. In deze studie kregen de ratten met diabetes of een voeding aangevuld met kurkuma of geen aanvulling. Na zes weken was de antioxidatie capaciteit bij de ratten zonder aanvulling met 30% afgenomen te zijn terwijl bij zij die kurkuma gegeten hadden was die capaciteit gelijk gebleven. De glutathionwaarden bleken in de groep zonder aanvullingen 50% lager te liggen terwijl dit in de kurkamagroep ongeveer 30% was dan bij ratten zonder diabetes. Het aantal ontsteking veroorzakende prote´nes bleek in de ratten zonder aanvulling wel verdubbeld te zijn terwijl in de kurkumagroep de verhoging slechts een paar % bedroeg in vergelijking met ratten zonder diabetes.

Effects of curcumin on retinal oxidative stress and inflammation in diabetes
Renu A. Kowluru and Mamta Kanwar
Abstract (provisional)

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

Background

Oxidative stress and inflammation are implicated in the pathogenesis of retinopathy in diabetes. The aim of this study is to examine the effect of curcumin, a polyphenol with antioxidant and anti-inflammatory properties, on diabetes-induced oxidative stress and inflammation in the retina of rats.

Methods

A group of streptozotocin-induced diabetic rats received powdered diet supplemented with 0.05% curcumin (w/w), and another group received diet without curcumin. The diets were initiated soon after induction of diabetes, and the rats were sacrificed 6 weeks after induction of diabetes. The retina was used to quantify oxidative stress and pro-inflammatory markers.

Results

Antioxidant capacity and the levels of intracellular antioxidant, GSH (reduced form of glutathione) levels were decreased by about 30-35%, and oxidatively modified DNA (8-OHdG) and nitrotyrosine levels were increased by 60-70% in the retina of diabetic rats. The levels of interleukin-1β (IL-1β) and vascular endothelial growth factor (VEGF) were elevated by 30% and 110% respectively, and the nuclear transcription factor (NF-kB) was activated by 2 fold. Curcumin administration prevented diabetes-induced decrease in the antioxidant capacity, and increase in 8-OHdG and nitrotyrosine; however, it had only partial beneficial effect on retinal GSH. Curcumin also inhibited diabetes-induced elevation in the levels of IL-1β, VEGF and NF-kB. The effects of curcumin were achieved without amelioration of the severity of hyperglycemia.

Conclusions

Thus, the beneficial effects of curcumin on the metabolic abnormalities postulated to be important in the development of diabetic retinopathy suggest that curcumin could have potential benefits in inhibiting the development of retinopathy in diabetic patients.

Nutrition & Metabolism 2007, 4:8 doi:10.1186/1743-7075-4-8 (Mei 2007) (Opm. Meer over kurkuma.) 

 

 

 

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