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Kurkuma bij artrose*
Uit een kleine Italiaanse studie blijkt dat kurkuma goed werkt doet bij artrose. In de studie kregen vijftig mensen met artrose in een of beide knieėn drie maanden lang dagelijks 1 gram van een speciaal extract van kurkuma. Na 3 maanden hadden alle deelnemers bijna 60% minder pijn en werd een forse vermindering (16x minder) van ontstekingsmarkers in het bloed gevonden. Alle deelnemers voelden zich ook aanzienlijk beter, gebruikten aanzienlijk minder pijnmedicatie en konden veel verder lopen. Het gebruikte, gepatenteerde extract is kurkuma met een toevoeging van sojalecithine voor een betere opname van de kurkuma.
Special Turmeric Extract Benefits Osteoarthritis Patients
A new clinical trial supports the benefits to people with osteoarthritis who used a unique extract of turmeric. Scientists in Italy have studied the pain-relief, increased flexibility, and other effects of a special, patented extract of the roots of turmeric, the flavorful spice that has been used for centuries as a traditional remedy. The characteristic yellow color of turmeric, which is found in many yellow mustards and yellow curry preparations, derives from compounds known collectively as curcuminoids, whose most abundant member is curcumin. Curcumin is difficult to absorb into the human bloodstream from the gastrointestinal tract when consumed orally.
Researchers in Italy selected 50 patients with X-ray diagnosed osteoarthritis in either one or both knees to evaluate if the special turmeric formulation called Meriva® could provide more benefits to their standard medical therapy. In this trial, the patients were split into two groups: the first one received standard medical treatment as determined by patients' physicians, while patients in the second group added the special curcumin extract to their standard medical treatment.
After 90 days, the following benefits were observed: Compared to the controls, patients in the Meriva group experienced a 58 percent decrease in their overall pain, stiffness and physical functionality as measured by the widely used medical scoring method developed by Western Ontario and McMaster Universities (WOMAC). In addition, the Social and Emotional Index (SEI) score resulted in a greater than 300 percent improvement in Meriva patients compared to patients not taking the curcumin extract. Blood tests indicated that in patients having elevated levels of C-reactive protein (CRP), a 16-fold decrease of this inflammation marker was observed in the Meriva group. Finally, the subjects using Meriva were able to reduce their reliance on standard painkillers (NSAIDs, non-steroidal anti-inflammatory drugs) by 63 percent compared to patients on conventional medical therapy alone.
Taken together, these data show that Meriva turmeric extract improves the clinical benefit of a standard NSAIDs-based treatment of osteoarthritis, making it possible for patients to decrease their medication load and increase its efficacy.
Consistent with data from other human studies on various types of turmeric extracts, Meriva demonstrated a high degree of safety without producing any serious adverse side effects.
"This is great news for people who suffer from osteoarthritis and the physicians who treat them," said Mark Blumenthal, Founder and Executive Director of the nonprofit American Botanical Council, an independent herbal medicine research and education organization in Austin, Texas.
"Turmeric has long been known to have anti-inflammatory and pain-relieving properties and this trial, on this special turmeric extract, is another important step towards validating the curcumin in turmeric as an increasingly popular herbal dietary supplement. When one considers the overall safety of turmeric extract and curcumin, especially compared to some of the pharmaceutical drugs which have had to be removed from the market due to serious safety concerns, the growing clinical evidence for the use of turmeric extract is compelling," he added.
The authors of this trial write that "curcumin is one of the most extensively investigated products of natural origin. Its broad spectrum of bioactivity and low oral toxicity have expanded its use to several clinical conditions. The Meriva curcumin extract used in this clinical trial is a special patented combination of curcumin with soybean-derived phosphatidylcholine (1:2 ratio). Produced and distributed by Indena SpA of Milan, Italy, the world's largest manufacturer of standardized botanical extracts for the food, dietary supplement, pharmaceutical and cosmetic industries. Meriva has recently been introduced into the market as a dietary supplement ingredient marketed in the USA and Europe. In this clinical study, Meriva capsules prepared by Thorne Research Inc. (Dover, Idaho, USA) were used at a dosage of 1 gram Meriva curcumin complex per day (standardized to contain 18-22 percent curcuminoids, and corresponding to 200 mg curcumin per day).
Turmeric is a traditional spice, food and medicine, native to Southeast Asia, and widely used in Ayurvedic system of traditional medicine in India. Turmeric is made from the roots and rhizomes (lateral roots) of the turmeric plant, a member of the same plant family as ginger. According to a recent review article, over 2,500 preclinical scientific investigations have supported the activity of curcumin from turmeric as a potential agent to treat directly or as an adjunct treatment for various chronic diseases such as inflammatory diseases, some forms of cancer and possibly also Alzheimer's disease. Turmeric's popularity has risen tremendously in the past few years as consumers learn more about its safety and wide spectrum of health benefits.
Belcaro G. 1, Cesarone M. R. 1, Dugall M. 1, Pellegrini L. 1, Ledda A. 1, Grossi M. G. 1, Togni S. 2, Appendino G. 3
1 Irvine3 Labs, Department of Biomedical Sciences, Chieti-Pescara University, Pescara, Italy;
2 Indena S.p.A., Milano, Italy;
3 Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Universitą del Piemonte Orientale, Novara, Italy
AIM: A proprietary complex of curcumin with soy phosphatidylcholine (Meriva®, Indena SpA) was evaluated in a registry study to define its efficacy in 50 patients with osteoarthritis (OA) at dosages corresponding to 200 mg curcumin per diem.
METHODS: OA signs/symptoms were evaluated by the WOMAC scores. Mobility was studied by walking performance (treadmill), and inflammatory status was assessed by measurements of C-reactive protein (CRP).
RESULTS: After three months of treatment, the global WOMAC score decreased by 58% (P<0.05), walking distance in the treadmill test was prolonged from 76 m to 332 m (P<0.05), and CRP levels decreased from 168 ± 18 to 11.3 ±. 4.1 mg/L in the subpopulation with high CRP. In comparison, the control group experienced only a modest improvement in these parameters (2% in the WOMAC score, from 82 m to 129 m in the treadmill test, and from 175 ± 12.3 to 112 ± 22.2 mg/L in the CRP plasma concentration), while the treatment costs (use of anti-inflammatory drugs, treatment and hospitalization) were reduced significantly in the treatment group.
CONCLUSION: These results show that Meriva® is clinically effective in the management and treatment of osteoarthritis and suggest that the increased stability and better absorption of curcumin induced by complexation with phospholipids have clinical relevance, setting the stage for larger and more prolonged studies. (Januari 2011)
Toevoeging van zwarte peper aan kurkuma geeft volgens onderzoek een vergelijkbare opname van kurkuma.