Mosterdzaad
tegen blaaskanker*
Uit een studie zowel in het laboratorium als bij ratten blijkt dat mosterdzaad
de groei van blaaskanker
tegengaat en zorgt dat geen verspreiding naar het omliggende spierweefsel kan
plaatsvinden. De mosterdplant behoort tot de kruisbloemigen.
Het is de bioactieve stof allyl isothiocyanaat
die zorgt voor deze werking.
Allyl isothiocyanate-rich mustard seed powder inhibits bladder cancer growth and
muscle invasion
Well-conceived diet-based approaches to protection against cancer and a variety
of other chronic diseases are sensible strategies for westerners to consider,
but they may be among the only viable strategies for the billions of medically
underserved people in much of the developing world. Thus, the mounting body of
evidence suggesting that certain cruciferous plants may be of benefit in this
regard should be directly applicable to designing such dietary interventions
and/or recommendations.
Mustard seed powder has been used in Chinese traditional medicine, Ayurvedic
medicine, and other traditional and folk medicines and cuisines for millennia.
Mustard (and the seed of this plant or "mustard seed") is a
cruciferous plant, and it is one of the richest known sources of allyl
isothiocyanate. Pure allyl isothiocyanate has already been shown in previously
published work by these investigators:
a. to selectively target human bladder cancer cells,
b. to spare normal human bladder epithelial cells,
c. to be selectively delivered to bladder cancer tissues via the urine, and
d. to be a potent inhibitor of bladder cancer development and muscle invasion in
an orthotopic rat bladder cancer model.
In light of human bladder tissue's unique exposure environment, bladder cancer
may be one of the best candidate tissues for a therapeutic, and perhaps for a
preventive approach that employs dietary isothiocyanates. These compounds and
their conjugates are excreted in the urine, build to very high concentrations
shortly following administration ONLY in the urinary bladder, and therefore are
able to exert their selective activity against tumor cells in the bladder
epithelium. It was shown in this paper that not only was bladder cancer growth
greatly inhibited, but that all muscle invasion was blocked, and VEGF, cyclin
B1, and caspase 3 were all significantly modulated by dietary mustard seed
powder.
This might be the perfect storm for bladder cancer.
Written by:
Jed W. Fahey, ScD as part of Beyond the Abstract on UroToday.com. This
initiative offers a method of publishing for the professional urology community.
Authors are given an opportunity to expand on the circumstances, limitations
etc... of their research by referencing the published abstract.
Allyl isothiocyanate-rich mustard seed powder inhibits bladder cancer growth and
muscle invasion
Abstract
Allyl isothiocyanate (AITC), which occurs in many common cruciferous vegetables,
was recently shown to be selectively delivered to bladder cancer tissues through
urinary excretion and to inhibit bladder cancer development in rats. The present
investigation was designed to test the hypothesis that AITC-containing
cruciferous vegetables also inhibit bladder cancer development. We focused on an
AITC-rich mustard seed powder (MSP-1). AITC was stably stored as its
glucosinolate precursor (sinigrin) in MSP-1. Upon addition of water, however,
sinigrin was readily hydrolyzed by the accompanying endogenous myrosinase. This
myrosinase was also required for full conversion of sinigrin to AITC in vivo,
while the matrix of MSP-1 had no effect on AITC bioavailability. Sinigrin itself
was not bioactive, whereas hydrated MSP-1 caused apoptosis and G2/M phase arrest
in bladder cancer cell lines in vitro. Comparison between hydrated MSP-1 and
pure sinigrin with added myrosinase suggested that the anticancer effect of MSP-1
was derived principally, if not entirely, from the AITC generated from sinigrin.
In an orthotopic rat bladder cancer model, oral MSP-1 at 71.5 mg/kg (sinigrin
dose of 9 µmol/kg) inhibited bladder cancer growth by 34.5% (P<0.05) and
blocked muscle invasion by 100%. Moreover, the anticancer activity was
associated with significant modulation of key cancer therapeutic targets,
including VEGF, cyclin B1 and caspase 3. On an equimolar basis, the anticancer
activity of AITC delivered as MSP-1 appears to be more robust than that of pure
AITC. MSP-1 is thus an attractive delivery vehicle for AITC and it strongly
inhibits bladder cancer development and progression.
Written by:
Bhattacharya A, Li Y, Wade KL, Paonessa JD, Fahey JW, Zhang Y.
Reference: Carcinogenesis. doi: 10.1093/carcin/bgq202 (Januari 2011)
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