Kurkuma en vitamine D tegen en bij de ziekte van Alzheimer*
Volgens een kleine Amerikaanse studie kan zowel kurkuma als
vitamine D effectief helpen tegen het ontstaan van de ziekte van
Alzheimer als ook bij de bestrijding van de ziekte. Beide voedingsstoffen kunnen het immuunsysteem zodanig activeren dat de abnormale afbraakproducten (bèta amyloïd) in de hersenen opgeruimd kunnen worden door macrofagen (veelvraten van beschadigde lichaamscellen). Bèta amyloïd vormt de zgn. plaques, het kenmerk van de ziekte van Alzheimer. Kurkuma verbetert de hechting van bèta amyloïd aan de macrofagen terwijl vitamine D de opname van bèta amyloïd door de macrofagen duidelijk verhoogd. Volgens de wetenschappers is het de combinatie van beide
voedingsstoffen die de beste resultaten geeft. Te gebruiken hoeveelheden zullen nog in verder onderzoek moeten worden vastgesteld.
Turmeric spice and vitamin D may help clear amyloid plaques found in Alzheimer's
UCLA scientists and colleagues from UC Riverside and the Human BioMolecular Research Institute have found that a form of vitamin D, together with a chemical found in turmeric spice called curcumin, may help stimulate the immune system to clear the brain of amyloid beta, which forms the plaques considered the hallmark of Alzheimer's disease.
The early research findings, which appear in the Journal of Alzheimer's Disease, may lead to new approaches in preventing and treating Alzheimer's by utilizing the property of vitamin D3 - a form of vitamin D - both alone and together with natural or synthetic curcumin to boost the immune system in protecting the brain against amyloid beta.
Vitamin D3 is an essential nutrient for bone and immune system health; its main source is sunshine, and it is synthesized through the skin. Deficiencies may occur during winter months or in those who spend a lot of time indoors, such as Alzheimer's patients.
"We hope that vitamin D3 and curcumin, both naturally occurring nutrients, may offer new preventive and treatment possibilities for Alzheimer's disease," said Dr. Milan Fiala, study author and a researcher at the David Geffen School of Medicine at UCLA and the Veterans Affairs Greater Los Angeles Healthcare System.
Using blood samples from nine Alzheimer's patients, one patient with mild cognitive impairment and three healthy control subjects, scientists isolated monocyte cells, which transform into macrophages that act as the immune system's clean-up crew, traveling through the brain and body and gobbling up waste products, including amyloid beta. Researchers incubated the macrophages with amyloid beta, vitamin D3 and natural or synthetic curcumin.
The synthetic curcuminoid compounds were developed in the laboratory of John Cashman at the Human BioMolecular Research Institute, a nonprofit institute dedicated to research on diseases of the human brain.Researchers found that naturally occurring curcumin was not readily absorbed, that it tended to break down quickly before it could be utilized and that its potency level was low, making it less effective than the new synthetic curcuminoids.
"We think some of the novel synthetic compounds will get around the shortcomings of curcumin and improve the therapeutic efficacy," Cashman said.
The team discovered that curcuminoids enhanced the surface binding of amyloid beta to macrophages and that vitamin D strongly stimulated the uptake and absorption of amyloid beta in macrophages in a majority of patients.
Previous research by the team demonstrated that the immune genes MGAT III and TLR-3 are associated with the immune system's ability to better ingest amyloid beta. In this earlier work, Fiala noted, it was shown that there are two types of Alzheimer's patients: Type 1 patients, who respond positively to curcuminoids, and Type II patients, who do not.
"Since vitamin D and curcumin work differently with the immune system, we may find that a combination of the two or each used alone may be more effective - depending on the individual patient," he said.
Fiala noted that this is early laboratory research and that no dosage of vitamin D or curcumin can be recommended at this point. Larger vitamin D and curcumin studies with more patients are planned.
http://www.ucla.edu
(Augustus
2009)
